Preparation and Spectroscopic Characterization of Ternary Inclusion Complexes of Ascorbyl Palmitate and Urea with γ-Cyclodextrin

A three-component inclusion complex of ascorbyl palmitate (ASCP), urea (UR), and γ-cyclodextrin (γCD) with a molar ratio 1/12 has been prepared for the first time using evaporation method (EVP method) grinding mixing (GM method). Also, we investigated changes in physicochemical properties complexes. The powder X-ray diffraction (PXRD) measurements showed ASCP, UR, γCD characteristic peaks physical mixture (PM) (AU (ASCP/UR = 1/12)/γCD 1/2). In GM 1/1), new were observed around 2θ 7.5° 16.6°, while derived from EVP 1/12) at 23.4° 24.9°. On other hand, 7.4° 16.6° (1/2). differential scanning calorimeter (DSC) measurement, an endothermic peak 83 °C was (1/1) sample, which is thought to originate phase transition hexagonal tetragonal form. An 113.9 also 1/12). However, no transition-derived or 1/12)-derived Near infrared (NIR) spectroscopy (1/2) shift CH group ASCP. NH UR shifted high low wavenumber sides 5032 cm−1 5108 OH shifted, ASCP broadened These results suggest that AU by mixed formed complexes